CBD and Drug Interactions


In a study concerning the safety and side effects of cannabidiol found that CBD at sufficient dosages will temporarily deactivate cytochrome P450 enzymes altering how we metabolize compounds. Has a pharmacist or doctor told you not to drink or eat grapefruit while taking a prescription medication? Grapefruit and CBD have a similar effect on P450, an enzyme found in the liver, which metabolizes different kinds of drugs in the human body. If taken in large doses, CBD can neutralize the effects of other medicinal products in the body's system. This side effect is also responsible for why cannabidiol counteracts the effects of THC.

Can you overdose on CBD?

Cannabidiol and other cannabinoids are know to be non-toxic, with no know fatal overdose levels ever reported. The Department of Health and Human Services states, ‘no signs of toxicity or serious side effects have been observed following chronic administration of cannabidiol to healthy volunteers (Cunha et al., Pharmacology 21:127-185, 1980), even in large acute doses of 700 mg/day (Consroe et al., Pharmacol, Biochem, Behav. 40:701-708, 1991).’ This is evidence that supports CBD being a safe substance.

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