5 Promising Cannabis Studies (part 2)


D. Lu, HI Ali, et al. from Texas A&M and UConn discussed a new technique of studying and characterizing compounds within cannabis (and beyond) that may affect the CB1 receptor differently than THC. THC is known as an orthosteric agonist or ligand of CB1, meaning THC is the “key” that fits squarely into the CB1 receptor site, or “lock.” However, allosteric ligands are compounds that can bind to the receptor at an alternate site, or locations away from the main “keyhole” to affect the intensity, duration, or character of the biological effect downstream of that receptor.In other words, using these allosteric sites of receptors instead of orthosteric (traditional docking sites) allow for more nuanced responses that emphasize some effects (e.g., anti-inflammatory, anti-pain, etc.), while avoiding other adverse, side effects (e.g., psychoactivity, anxiety, paranoia, etc.).

Reference:

http://onlinelibrary.wiley.com/doi/10.1111/jnc.12115/full


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