Killing Breast Cancer Cells with Cannabidiol (CBD)

Breast cancer is the most common cancer among women in the United States. It is the second leading cause of cancer related deaths. A paper published by the American Association for Cancer Research found that CBD inflicts programmed cell death (PCD) in breast cancer cells. Cannabidiol (BD) is a non-psychoactive phytocannabinoid derived from the cannabis plant that has medicinal qualities. One of the most important health benefits is their anti-inflammatory property. Numerous diseases states arise out of chronic inflammation; such as, depression, dementias including alzheimer's, cancer, arthritis and other autoimmune disorders. The cannabinoids, being immunomodulators, interrupt the cytokine inflammatory cascade so that local inflammation does not result in tissue pathology. The U.S. Government's National Cancer Institute has acknowledge the power of CBD as a anticancer agent.

The American Association for Cancer Research (AACR) analyzed the effects of the Cannabis sativa constituent, cannabidiol (CBD) by administering CBD to cancerous cell colonies and observing the decline. They found that CBD inhibited the survival of both estrogen receptor-positive, and estrogen receptor-negative breast cell lines. The molecules in CBD work by binding to certain cell receptors that make up the human endocannabinoid system. These are the CB1 and CB2 receptors. CBD induced both apoptosis and autophagy induced death in breast cancer cells. Apoptosis (cell suicide) plays a vital role within our bodies. It is a form of cell death that facilitates the elimination of old and unhealthy cells without the release of harmful substances. Autophagy (cell recycling) is another normal physiological process by which the body breaks down unwanted cells. This suggest that CBD preferentially kills breast cancer cells, while minimizing damage to normal breast tissue.

Our endocannabinoid system can maintain metabolic homeostasis and even cure serious disease, but the body produces only small amounts of anandamide, and 2-AG, enough to maintain the body, but not enough to overcome chronic stress, illness, injury, or malnutrition. Cannabis is the only plant know that produces phytocannabinoids that mimic our own endocannabinoids. The benefits from taking CBD is that it's natural to our biology and can not harm our tissues and systems.

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